Publications

Peer-Reviewed Articles

Anfray A, Schaeffer S, Hattori Y, Santisteban MM, Casey N, Wang G, Strickland M, Zhou P, Holtzman D, Anrather J, Park L, Iadecola C. A cell-autonomous role for border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury. Nat Neurosci. 2024. PMID: 39294490

Santisteban MM#, Schaeffer S, Anfray A, Faraco G, Brea Lopez D, Wang G, Sobanko MJ, Sciortino R, Racchumi G, Waisman A, Park L, Anrather J, Iadecola C#. Meningeal IL-17 producing T cells mediated cognitive impairment in salt-sensitive hypertension. Nat Neurosci. 2024; 27:63-77. PMID: 38049579

Santisteban MM#, Ahn S, Lane D, Faraco G, Garcia-Bonilla L, Racchumi G, Poon C, Schaeffer S, Segarra SG, Korbelin J, Anrather J, Iadecola C#. Endothelium-macrophage crosstalk mediates blood-brain barrier dysfunction in hypertension. Hypertension. 2020; 76:795-807. PMID: 32654560

Hypertension Journal Top Paper Award 2020

Faraco G, Hochrainer K, Segarra SG, Schaeffer S, Santisteban MM, Menon A, Jiang H, Holtzman DM, Anrather J, Iadecola C. Dietary salt promotes cognitive impairment through tau phosphorylation. Nature. 2019; 574:686-690. PMID: 31645758

Publisher Correction: Nature. 2020; 578:E9. 

Editorial: Nat Rev Neurol. 2020;16:2-3.

Ahmari N, Santisteban MM, Miller DR, Geis NM, Larkin RM, Redler TL, Denson H, Khoshbouei H, Baekey DM, Raizada MK, Zubcevic J. Elevated bone marrow sympathetic drive precedes systemic inflammation in angiotensin II hypertension. Am J Physiol Heart Circ Physiol. 2019; 317:HH279-H289. PMID: 31150271

Faraco G, Brea D, Garcia-Bonilla L, Wang G, Racchumi G, Chang H, Buendia I, Koizumi K, Santisteban MM, Sugiyama Y, Murphy M, Voss H, Anrather J, Iadecola C. Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Nature Neurosci. 2018; 21:240-249. PMID: 29335605

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Editorials: Nat Neurosci. 2018;21:154-155. Nat Rev Neurosci. 2018;19:122. 

Zubcevic J, Santisteban MM, Perez PD, Arocha R, Hiller H, Malphurs WL, Colon-Perez LM, Sharma RK, de Kloet A, Karuse EG, Febo M, Raizada MK. A single angiotensin II hypertensive stimulus is associated with prolonged neuronal and immune system activation in Wistar-Kyoto rats. Front Physiol. 2017;8:592. PMID: 28912720 

Santisteban MM*, Qi Y*, Zubcevic J, Kim S, Yang T, Shenoy V, Cole-Jeffrey CT, Lobaton GO, Stewart DC, Rubiano A, Simmons CS, Garcia-Pereira F, Johnson RD, Pepine CJ, Raizada MK. Hypertension-linked pathophysiological alterations in the gut. Circ Res. 2017;120:312-323. PMID: 27799253 

Editorials: Circ Res. 2017;120:249-251. Nat Rev Nephrol. 2017;13:3. 

Faraco G, Sugiyama Y, Lane D, Garcia Bonilla L, Chang H, Santisteban MM, Racchumi G, Murphy M, Van Rooijen N, Anrather J, Iadecola C. Perivascular macrophages mediate the neurovascular and cognitive dysfunction of hypertension. J Clin Inv. 2016;126:4674-4689. PMID: 27841763 

Editorial: J Clin Invest. 2016;126:4393-4395.

Stewart D*, Rubiano A*, Santisteban MM, Shenoy V, Qi Y, Pepine CJ, Raizada MK, Simmons CS. Hypertension-linked mechanical changes of rat gut. Acta Biomaterialia. 2016;45:296-302. PMID: 27567964

Santisteban MM, Ahmari N, Marulanda Carvajal J, Zingler MB, Qi Y, Kim S, Joseph J, Garcia-Pereira F, Johnson RD, Shenoy V, Raizada MK, Zubcevic J. Involvement of bone marrow cells and neuroinflammation in hypertension. Circ Res. 2015;117:178-91. PMID: 25963715 

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Editorial: Circ Res. 2015;117:119-20.

Yang T*, Santisteban MM*, Rodriguez V*, Li E, Ahmari N, Marulanda J,  Zadeh M, Gong M, Qi Y, Zubcevic J, Sahay B, Pepine CJ, Raizada MK, Mohamadzadeh M. Gut dysbiosis is linked to hypertension. Hypertension. 2015; 65: 1331-1340. PMID: 25870193   

Zubcevic J, Jun JY, Kim S, Perez PD, Afzal A, Shan Z, Li W, Santisteban MM, Yuan W, Febo M, Mocco J, Feng Y, Scott E, Baekey DM, and Raizada MK. Altered inflammatory response is associated with an impaired autonomic input to the bone marrow in the spontaneously hypertensive rat. Hypertension. 2014; 63(3):542-50. PMID: 24366083 

Review Articles and Editorial Commentaries

Santisteban MM, Iadecola C. Incompetent neck valves threaten the aging brain. Nat Aging. 2024. PMID: 39261743

Murray DD, Williams CR, Gaddy JA, Rogers CD, Kirabo A, Santisteban MM, Wanjalla CN, Williams EM, Sweetwyne MT, Damo SM, Murray SA, Stokes D, Hinton A Jr. The power of junior faculty mentoring committees. J Cell Physiol. 2024; e31360. PMID: 38962842

Zarate SM, Kirabo A, Hinton AO Jr., Santisteban MM. Neuroimmunology of cardiovascular disease. Curr Hypertens Rep. 2024;26:339-347. PMID: 38613621

Santisteban MM, Iadecola C. A deeper dive into amyloid clearance by meningeal lymphatic vessels. Nat Cardiovasc Res. 2024;3:407-409. PMID: 39196214

Baggeroer CE, Cambronero FE, Savan NA, Jefferson AL, Santisteban MM. Basic mechanisms of brain injury and cognitive decline in hypertension. Hypertension. 2024;81:34-44. PMID: 37732473

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Neikirk K, Marshall AG, Santisteban MM, Hinton A Jr. BNIP as a new tool to promote healthy brain aging. Aging Cell. 2024;23:e14042. PMID: 38030595

Santisteban MM#, Iadecola C, Carnavale D#. Hypertension, neurovascular dysfunction, and cognitive impairment. Hypertension. 2023;80:22-34. PMID: 36129176

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Glodzik L, Santisteban MM. Blood-brain barrier crossing renin-angiotensin system drugs: considerations for dementia and cognitive decline. Hypertension. 2021; 78:644-646.  PMID: 34379433

Santisteban MM, Iadecola C. Hypertension, dietary salt, and cognitive impairment. J Cereb Blood Flow Metab. 2018;38:2112-28. PMID: 30295560

Santisteban MM, Kim S, Pepine CJ, Raizada MK. Brain-gut-bone marrow axis: implications for hypertension and related therapeutics. Circ Res. 2016; 118:1327-36. PMID: 27081113

Zubcevic J, Santisteban MM, Pitts T, Baekey DM, Perez PD, Bolser DC, Febo M, Raizada MK. Functional neural-bone marrow pathways: Implications in hypertension and cardiovascular disease. Hypertension. 2014; 63: e129-39. PMID: 24688127

Santisteban MM, Zubcevic J, Baekey DM, Raizada MK. Dysfunctional brain-bone marrow communication: A paradigm shift in the pathophysiology of hypertension. Curr Hypertens Rep. 2013; 15(4):377-89. PMID: 23715920

Pre-Prints

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